Obesity is a major public health challenge. Children and adults who are obese have greater risk of developing cardiovascular disease, diabetes, and premature death. Sedentary time is an important contributor to obesity, and the environments in which we live and work are engineered to promote sedentary behaviors. Experts in Industrial Design and Health Promotion at a major university in U.S. have forged a partnership to identify targeted solutions to reduce sedentary behavior in key contexts for children (i.e., classrooms) and adults (i.e., worksites). This paper introduces how expertise in design and health promotion was leveraged to form this collaboration and to target innovative designs and evaluations that will reduce sitting time in schools and worksites via redesigning school and office desks.